Gene specific siRNA selector
نویسندگان
چکیده
Small interfering RNA (siRNA) is used in functional genomics applications to decrease the expression of a target gene, which may yield a biological effect that suggests a function for the target gene. The siRNA design tool scans a target gene for candidate siRNA sequences that satisfy user-adjustable rules. Selected candidates are then screened to identify those siRNA sequences that are specific to the gene of interest.
منابع مشابه
STUDY OF HMGA2 GENE INHIBITION WITH SPECIFIC SHRNA AND SIRNA AND INVESTIGATION OF CORRESPONDING EFFECTS ON DOWNSTREAM GENE EXPRESSION IN MDA-MB-231 CANCER CELLS: A BIOINFORMATIC AND EXPERIMENTAL STUDY
Background & Aims: The use of siRNA to silence gene expression is increasingly expanding today. The aim of this study is to bioinformatically and experimentally investigate the inhibition of the HMGA2 gene and its corresponding effects on downstream genes expression rate in MDA-MB-231 cancer cell treated by shRNA and siRNA specific to HMGA2. Materials & Methods: To perform this bioinformatic a...
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ورودعنوان ژورنال:
- Bioinformatics
دوره 20 3 شماره
صفحات -
تاریخ انتشار 2004